EVIDENCE BASED RESEARCH KETOGENIC DIET AND SCHIZOPHRENIA

What variables are you interested in learning about-list independent and dependent variables

Resources we used: Gilbert-Jaramillo, J., Vargas-Pico, D., Espinosa-Mendoza, T., Falk, S., Llanos-Fernandez, K., Guerrero-Haro, J., Orellana-Roman, C., Poveda-Loor, C., Valdevila-Figueira, J., & Palmer, C. (2018). The effects of the ketogenic diet on psychiatric symptomatology, weight and metabolic dysfunction in schizophrenia patients. Clinical Nutrition and Metabolism, 1(1). https://doi.org/10.15761/cnm.1000105 (Links to an external site.)

Kraeuter, A. K., Loxton, H., Lima, B. C., Rudd, D., & Sarnyai, Z. (2015). Ketogenic diet reverses behavioral abnormalities in an acute NMDA receptor hypofunction model of schizophrenia. Schizophrenia Research, 169(1–3), 491–493. https://doi.org/10.1016/j.schres.2015.10.041 (Links to an external site.)

Kraeuter, A. K., Mashavave, T., Suvarna, A., van den Buuse, M., & Sarnyai, Z. (2020). Effects of beta-hydroxybutyrate administration on MK-801-induced schizophrenia-like behaviour in mice. Psychopharmacology, 237(5), 1397–1405. https://doi.org/10.1007/s00213-020-05467-2 (Links to an external site.)
Kraft, B. D., & Westman, E. C. (2009). Schizophrenia, gluten, and low-carbohydrate, ketogenic diets: a case report and review of the literature. Nutrition & metabolism, 6, 10. https://doi.org/10.1186/1743-7075-6-10

Norwitz, N. G., Dalai, S. S., & Palmer, C. M. (2020). Ketogenic diet as a metabolic treatment for mental illness. Current opinion in endocrinology, diabetes, and obesity, 27(5), 269–274. https://doi.org/10.1097/MED.0000000000000564Links to an external site.

Katie:

Włodarczyk, A., Wiglusz, M. S., & Cubała, W. J. (2018). Ketogenic diet for schizophrenia: Nutritional approach to antipsychotic treatment. Medical hypotheses, 118, 74–77. https://doi.org/10.1016/j.mehy.2018.06.022Links to an external site.

Lea:

Sarnyai, Z., Kraeuter, A. K., & Palmer, C. M. (2019). Ketogenic diet for schizophrenia: clinical implication. Current opinion in psychiatry, 32(5), 394–401. https://doi.org/10.1097/YCO.0000000000000535Links to an external site.

Carlos: Pick the one that you want and that is left:

Kraeuter, A. K., van den Buuse, M., & Sarnyai, Z. (2019). Ketogenic diet prevents impaired prepulse inhibition of startle in an acute NMDA receptor hypofunction model of schizophrenia. Schizophrenia research, 206, 244–250. https://doi.org/10.1016/j.schres.2018.11.011 (Links to an external site.) and/or

Palmer, C. M., Gilbert-Jaramillo, J., & Westman, E. C. (2019). The ketogenic diet and remission of psychotic symptoms in schizophrenia: Two case studies. Schizophrenia research, 208, 439–440. https://doi.org/10.1016/j.schres.2019.03.019Links to an external site.

Pacheco, A., Easterling, W. S., & Pryer, M. W. (1965). A Pilot Study of the Ketogenic Diet in Schizophrenia. American Journal of Psychiatry, 121(11), 1110–1111. https://doi.org/10.1176/ajp.121.11.1110 (Links to an external site.)

Sarnyai, Z., & Palmer, C. M. (2020). Ketogenic Therapy in Serious Mental Illness: Emerging Evidence. International Journal of Neuropsychopharmacology, 23(7), 434–439. https://doi.org/10.1093/ijnp/pyaa036 (Links to an external site.)

Włodarczyk, A., Wiglusz, M. S., & Cubała, W. J. (2018). Ketogenic diet for schizophrenia: Nutritional approach to antipsychotic treatment. ScienceDirect. https://www.sciencedirect.com/science/article/pii/S0306987718304717
What tools/instruments are you going to use to capture data about these variables
Name & descriiption of each
Title, type of questions, way they are scored
2) Data Collection:

What data (measurements) will be collected
Name variables and associated instrument
When will the data be collected
Identify and justify frequency of data collection
Who will collect the data
Identify and justify who will collect data
Important to think about human subject protection issues
3) Data Analysis:

Which analysis procedures will be used to answer your questions
List question / hypothesis to be analyzed and identify procedure for each